Charles Brenner, PhD
Alfred E Mann Chair
Department of Diabetes & Cancer Metabolism
Diabetes & Metabolism Research Institute and
MCB of Cancer Program
Beckman Research Institute
City of Hope National Medical Center
Duarte, CA 91010 USA
- Wesleyan University (1979-1983)
- Middletown, CT 06457
- B.A. with Honors in Biology
- 1983-1985 Research Associate for Anthony J. Brake
Chiron Corporation, Emeryville, CA
- 1986-1988 Research Associate for Kunihiro Matsumoto
DNAX Research Institute, Palo Alto, CA
- 1996-2000 Assistant Professor of Microbiology & Immunology
Jefferson Medical College
Member, Program in Structural Biology, Kimmel Cancer Center
- 2000-2003 Associate Professor of Microbiology & Immunology
Jefferson Medical College
Director, Structural Biology & Bioinformatics Program, Kimmel Cancer Center
Thomas Jefferson University, Philadelphia, PA
- 2003-2007 Associate Professor of Genetics and of Biochemistry
Dartmouth Medical School
- 2003-2008 Director, Cancer Mechanisms Program
Norris Cotton Cancer Center
- 2005-2009 Scientific Director
Comprehensive Thoracic Oncology Program
Dartmouth-Hitchcock Medical Center
- 2007-2009 Professor of Genetics and of Biochemistry
Dartmouth Medical School
- 2008-2009 Associate Director for Basic Sciences
Norris Cotton Cancer Center, Lebanon, NH
- 2009-2020 Professor and DEO of Biochemistry
Carver College of Medicine
University of Iowa, Iowa City, IA
- 2010-2020 Professor of Internal Medicine and Roy J. Carver Chair in Biochemistry
Carver College of Medicine
University of Iowa, Iowa City, IA
- 2011-2020 Founding Co-Director, Obesity Research and Education Initiative
Office of the Provost
University of Iowa, Iowa City, IA
Selected Honors and Awards
- 1979-1980 Connecticut State Scholar
- 1979-1983 National Merit Scholar
- 1988-1992 Program in Cancer Biology trainee of the NCI
- 1993-1996 Fellow of the Leukemia Society of America
- 1994 Leukemia Society of America Short-Term Scientific Exchange Award
- 1998-2000 Basil O’Connor Scholar of the March of Dimes Birth Defects Foundation
- 1998-2000 Beckman Young Investigator of the Arnold and Mabel Beckman Foundation
- 1998-2001 Burroughs Wellcome Fund New Investigator in the Basic Pharmacological Sciences
- 2007 William E.M. Lands Lecturer in Nutritional Biochemistry, University of Michigan
- 2008-2009 Lung Cancer Research Foundation Award
- 2010- present Roy J. Carver Chair of Biochemistry
- 2012 Holden Comprehensive Cancer Center Oberley Award
- 2013 Fellow of the American Association for the Advancement of Science
- 2014 State of Iowa Regents Award for Faculty Excellence
- 2015 Ackerson Student Lecturer in Biochemistry & Redox Biology, University of Nebraska
- 2015 Keynote Lecturer at the Brown University Pathobiology Retreat
- 2016 ASBMB Award for Exemplary Contributions to Education
- 2016 CNIO Distinguished Lecturer, Madrid
- 2018 Dartmouth Technology Transfer Innovation and Commercialization Award
- 2018 Keynote Lecturer at 15th International Symposium on Milk Genomics & Human Health, Sacramento
- 2019 Keynote Lecturer at Norway AGE Conference on NAD, Oslo
- 2020 Mary Swartz Rose Senior Investigator Award, American Society of Nutrition
- 1998 Organizer of Wesleyan University Alumni Symposium on Biology and the New Pharmacopaeia
- 2004-2007 F04B, Biophysical and Biochemical Sciences Fellowship Study Section, National Institutes of Health
- 2004 Structural Biology Program, Department of Energy
- 2005-2007 Beckman Young Investigator Review Committee, Arnold and Mabel Beckman Foundation
- 2008 American Federation for Aging Research National Scientific Advisory Council
- 2008-2012 ICP1, International Cooperative Projects Study Section, National Institutes of Health
- 2009-2012 ASBMB Publications Committee (chair, 2011-2012)
- 2014-present Scientific Advisory Board, ChromaDex, Inc
- 2016-2017 Co-founder and Chief Scientific Advisor, Prohealthspan, LLC
- 2016-2020 INMP, Integrated Nutrition & Metabolic Processes Study Section, National Institutes of Health
- 2017-present Chief Scientific Adviser, ChromaDex, Inc
- 2017-present Scientific Advisory Board, Cytokinetics, Inc
- 1997-2003 Yeast Transformation section of BI532
- 1997-2003 X-ray Crystallography section of PR613 including the Difference Patterson Function
- 1999-2003 Yeast Genetics section of GE611
- 1999-2003 Yeast Cell Cycle and Cell Cycle Checkpoints section of GE636
- 2004-2009 NAD+ Metabolism section of the MCB Core Course
- 2005-2008 Genetics 144, Oncogenomics
- 2005-2007 Yeast Genetics section of the MCB Core Course
- 2010-2018 Carbohydrate Metabolism Section of BIOC:3120
- 2019-2020 Lipid and nucleotide metabolism section of BIOC:3130
- A. Brake, C. Brenner, R. Najarian, P. Laybourn & J. Merryweather, “Structure of Genes Encoding Precursors of the Yeast Peptide Mating Pheromone a-Factor” Protein Transport and Secretion, M. J. Gething, ed., pp. 103-108 (1985). Download reprint
- I. Miyajima, M. Nakafuku, N. Nakayama, C. Brenner, A. Miyajima, K. Kaibuchi, K. Arai, Y. Kaziro & K. Matsumoto, “GPA1, A Haploid-Specific Essential Gene, Encodes a Yeast Homolog of Mammalian G Protein Which May Be Involved in Mating Factor Signal Transduction,” Cell, v. 50, pp. 1011-1019 (1987). Download reprint
- C. Brenner, N. Nakayama, M. Goebl, K. Tanaka, A. Toh-e & K. Matsumoto, “CDC33 Encodes mRNA Cap-Binding Protein eIF-4E of Saccharomyces cerevisiae,” Molecular and Cellular Biology, v. 8, pp. 3556-3559 (1988). Download reprint
- K. Matsumoto, M. Nakafuku, N. Nakayama, I. Miyajima, K. Kaibuchi, A. Miyajima, C. Brenner, K. Arai & Y. Kaziro, “The Role of G Proteins in Yeast Signal Transduction,” Cold Spring Harbor Symposia on Quantitative Biology, v. 53, pp. 567-575 (1988). Download reprint
- R.S. Fuller, C. Brenner, P. Gluschankof & C.A. Wilcox, “The Yeast Prohormone-Processing Kex2 Protease, an Enzyme with Specificity for Paired Basic Residues,” in Methods in Protein Sequence Analysis, Jornvall, H., Hoog, J.-O. & Gustavsson, A.-M., pp. 205-214 (1991). Download reprint
- C. Brenner & R.S. Fuller, “Structural and Enzymatic Characterization of a Purified Prohormone-Processing Enzyme: Secreted, Soluble Kex2 Protease,” Proceedings of the National Academy of Sciences, v. 89, pp. 922-926 (1992). Download reprint
- H. Angliker, P. Wikstrom, E. Shaw, C. Brenner & R.S. Fuller, “The Synthesis of Inhibitors of Processing Proteases and Their Action on the Kex2 Protease of Yeast,” Biochemistry Journal, v. 293, pp. 75-81 (1993). Download reprint
- C. Brenner, A. Bevan & R.S. Fuller, “One-Step Site-Directed Mutagenesis of The Kex2 Protease Oxyanion Hole,”Current Biology, v. 3, pp. 498-506 (1993). Download reprint
- C. Brenner, A. Bevan & R. S. Fuller, “Methods for Analyzing the Specificity and Activity of a Prohormone-Processing Enzyme, the Yeast Kex2 Protease (Kexin),” Methods in Enzymology, v. 244, pp. 152-167 (1994). Download reprint
- C. Brenner, “Reducing the Energy Barrier to Crystallization, review of Crystallization of Nucleic Acids and Proteins,” Protein Science, v. 3, pp. 2471-2472 (1994). Download reprint
- H. Diefenbach-Jagger, C. Brenner, B.E. Kemp, W. Baron, J. McLean, T.J. Martin & J.M. Moseley, “Arg21 is the Preferred Kexin Cleavage Site in Parathyroid-Hormone-Related Protein,” European Journal of Biochemistry, v. 229, pp. 91-98 (1995). Download reprint
- C. Brenner, P. Garrison, J. Gilmour, D. Peisach, D. Ringe, G.A. Petsko & J.M. Lowenstein, “Crystal Structures of Hint Demonstrate that Histidine Triad Proteins are GalT-related Nucleotide-Binding Proteins,” Nature Structural Biology, v. 4, pp. 231-238 (1997). View Hint-GMP, Hint-Adenosine, Hint-8-Br-AMP, Apo-Hint entries at the Protein Data Bank. Download reprint
- C. Brenner, H.C. Pace, P.N. Garrison, A.K. Robinson, A. Rosler, X.H. Liu, G.M. Blackburn, C.M. Croce, K. Huebner & L.D. Barnes, “Purification and Crystallization of Complexes Modeling the Active State of the Fragile Histidine Triad Protein,” Protein Engineering, v. 10, pp. 1461-1463 (1997). Download reprint
- G.M. Blackburn, X. Liu, A. Rosler & C. Brenner, “Two Hydrolase Resistant Analogues of Diadenosine 5′,5”’-P1,P3-triphosphate for Studies with Fhit, the Human Fragile Histidine Triad Protein,” Nucleosides and Nucleotides, v. 17, pp. 301-308 (1998). Download reprint
- H.C. Pace, P.N. Garrison, A.K. Robinson, L.D. Barnes, A. Draganescu, A. Rosler, G.M. Blackburn, Z. Siprashvili, C.M. Croce, K. Huebner & C. Brenner, “Genetic, Biochemical and Crystallographic Characterization of Fhit-Substrate Complexes as the Active Signaling Form of Fhit,” Proceedings of the National Academy of Sciences, v. 95, pp. 5484-5489 (1998). View Fhit-IB2, Fhit H96N-IB2 entries at the Protein Data Bank. Download reprint
- Y. Pekarsky, M. Campiglio, Z. Siprashvili, T. Druck, Y. Sedkov, S. Tillib, A. Draganescu, P. Wermuth, J.H. Rothman, K. Huebner, A.M. Buchberg, A. Mazo, C. Brenner & C.M. Croce, “Nitrilase and Fhit Homologs are Encoded as Fusion Proteins in Drosophila melanogaster and Caenorhabditis elegans,” Proceedings of the National Academy of Sciences, v. 95, pp. 8744-8749 (1998). Download reprint
- A. Bevan, C. Brenner & R.S. Fuller, “Quantitative Assessment of Enzyme Specificity in vivo: P2 Recognition by Kex2 Protease Defined in a Genetic System,” Proceedings of the National Academy of Sciences, v. 95, pp. 10384-10389 (1998). Download reprint
- X. Liu, C. Brenner, A. Guranowski, E. Starzynska & G.M. Blackburn, “New Tripodal, ‘Supercharged Analogs’ of Adenosine Nucleotides: Inhibitors for the Fhit Ap3A Hydrolase,” Angewandte Chemie International Edition, v. 38, pp. 1244-1247 (1999). Download reprint
- C. Brenner, “Fhit-Substrate Complexes: A New Paradigm in Reversible Protein Phosphorylation,” Proceedings of the XIVth International Conference on Phosphate Chemistry, Phosphorus, Sulfur and Silicon, v. 144-146, pp. 745-748 (1999). Download reprint
- K. Huebner, G. Sozzi, C. Brenner, M.A. Pierotti & C.M. Croce, “Fhit Loss in Lung Cancer: Diagnostic and Therapeutic Implications,” Advances in Oncology, v. 15, pp. 3-10 (1999). Download reprint
- M.J. Fernandes, A.A. Finnegan, L.D. Siracusa, C. Brenner, N.N. Iscove & B. Calabretta, “Characterization of a Novel Receptor that Maps Near the Natural Killer Gene Complex: Demonstration of Carbohydrate Binding and Expression in Hematopoietic Cells,” Cancer Research, v. 59, pp. 2709-2717 (1999). Download reprint
- C. Brenner, P. Bieganowski, H.C. Pace & K. Huebner, “The Histidine Triad Superfamily of Nucleotide-Binding Proteins,” Journal of Cellular Physiology, v. 181, pp. 179-187 (1999). Download reprint. Please see ref. 38 for the most current review on HIT proteins.
- A. Draganescu, S.C. Hodawadekar, K.R. Gee & C. Brenner, “Fhit-Nucleotide Specificity Probed with Novel Fluorescent and Fluorogenic Substrates,” Journal of Biological Chemistry, v. 275, pp. 4555-4560 (2000). Download reprint The reagents can be ordered from Molecular Probes, Inc.
- C. Brenner, “A Cultivated Taste for Yeast,” Genome Biology, v. 1, pp. reviews103.1-103.4 (2000). Download reprint
- C. Brenner, “Fhitness and Cancer in the Mouse,” Trends in Genetics, v. 16, 294 (2000). Download reprint
- H.C. Pace, S.C. Hodawadekar, A. Draganescu, J. Huang, P. Bieganowski, Y. Pekarsky, C.M. Croce & C. Brenner, “Crystal Structure of the Worm NitFhit Rosetta Stone Protein Reveals a Nit Tetramer Binding Two Fhit Dimers,” Current Biology, v. 10, pp. 607-617 (2000). View NitFhit at the Protein Data Bank. Download reprint
- C. Brenner, “Condensing the RNA World,” Trends in Biochemical Sciences, v. 25, 485 (2000). Download reprint
- J.R. Boyne, H.M. Yosuf, P. Bieganowski, C. Brenner & C. Price, “Yeast Myosin Light Chain, Mlc1p, Interacts with Both IQGAP and Class II Myosin to Effect Cytokinesis,” Journal of Cell Science, v. 113, pp. 4533-4543 (2000). Download reprint
- H.C. Pace & C. Brenner, “The Nitrilase Superfamily: Classification, Structure and Function,” Genome Biology, v. 2, pp. reviews0001.1-0001.9 (2001). Download reprint. See supplemental data file at Genome Biology.
- L. Daheron, T. Zenz, L.D. Siracusa, C. Brenner & B. Calabretta, ” Molecular Cloning of Ian4: a BCR/ABL-Induced Gene that Encodes an Outer Membrane Mitochondrial Protein with GTP-Binding Activity, ” Nucleic Acids Research, v. 29, pp. 1308-1316 (2001). Download reprint
- A.G. McLennan, L.D. Barnes, G.M. Blackburn, C. Brenner, A. Guranowski, A.D. Miller, J.M. Rovira, P. Rotllan, B. Soria, J.A. Tanner & A. Sillero, “Recent Developments in the Study of the Intracellular Function of Diadenosine Polyphosphates,” Drug Development Research, v. 52, pp. 249-259 (2001). Download reprint
- J.M. Varnum, J. Baraniak, R. Kaczmarek, W.J. Stec & C. Brenner, “Di-, Tri- and Tetra-5-O-Phosphorothioadenosyl Substituted Polyols as Inhibitors of Fhit: Importance of the Alpha-Beta Bridging Oxygen and Beta Phosphorus Replacement, ” BMC Chemical Biology, v. 1, 3 (2001). Download reprint
- C. Brenner, “FHIT” in the Wiley Encyclopedia of Molecular Medicine, v. 2, Thomas E. Creighton, Ed., pp. 1274-1275 (2001). Download reprint
- D.H. Klaubert, K.R. Gee & C.M. Brenner, “Phosphate-Bound Polyazaindacene Derivatives of Nucleotides,” US Patent 6,323,186, issued November 27, 2001. Download reprint
- S.K. Milano, H.C. Pace, Y.-M. Kim, C. Brenner & J. Benovic, “Scaffolding Functions of Arrestin-2 Revealed by Crystal Structure and Mutagenesis,” Biochemistry, v. 41, pp. 3321-3328 (2002). View Arrestin-2 at the Protein Data Bank. Download reprint
- P. Bieganowski, P.N. Garrison, S.C. Hodawadekar, G. Faye, L.D. Barnes & C. Brenner, “Adenosine Monophosphoramidase Activity of Hint and Hnt1 Supports Function of Kin28, Ccl1 and Tfb3, ” Journal of Biological Chemistry, v. 277, pp. 10852-10860 (2002). Download reprint
- M. Rubio-Texeira, J.M. Varnum, P. Bieganowski & C. Brenner, “Control of Dinucleoside Polyphosphates by the FHIT-Homologous HNT2 Gene, Adenine Biosynthesis, and Heat Shock in Saccharomyces cerevisiae,” BMC Molecular Biology, v. 3, 7 (2002). Download reprint
- C. Brenner, “Hint, Fhit and GalT: Function, Structure, Evolution and Mechanism of Three Branches of the Histidine Triad Superfamily of Nucleotide Hydrolases and Transferases,” Biochemistry, v. 41, pp. 9003-9014 (2002). Download reprint
- C. Brenner, “Catalysis in the Nitrilase Superfamily,” Current Opinion in Structural Biology, v. 6, pp. 775-782 (2002). Download reprint
- A. Owczarek, R. Kaczmarek, B. Mikolajczyk, E. Wasilewska, D. Korczynski, J. Baraniak, M. Koziolkiewicz, W.J. Stec WJ & C. Brenner, “Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5′-O-phosphorothioyl)glycerols,”Nucleosides, Nucleotides and Nucleic Acids, v. 22, pp. 797-9 (2003).
- F. Trapasso, A. Krakowiak, R. Cesari, J. Arkles, S. Yendamuri, H. Ishii, A. Vecchione, T. Kuroki, P. Bieganowski, H.C. Pace, K. Huebner, C.M. Croce & C. Brenner, “Designed FHIT Alleles Establish that Fhit-Induced Apoptosis in Cancer Cells is Limited by Substrate-Binding,” Proceedings of the National Academy of Sciences, v. 100, pp. 1592-1597 (2003). Download reprint
- H.C. Pace & C. Brenner, “Feminizing Chicks: A Model for Avian Sex Determination Based on Titration of Hint Enzyme Activity and the Predicted Structure of an Asw-Hint Heterodimer,” Genome Biology, v. 4, R18 (2003). Download reprint
- P. Bieganowski, H.C. Pace & C. Brenner, “Eukaryotic NAD+ Synthetase Qns1 Contains an Essential, Obligate Intramolecular Thiol Glutamine Amidotransferase Domain Related to Nitrilase,” Journal of Biological Chemistry, v. 278, pp. 33049-33055 (2003). Download reprint
- P. Bieganowski & C. Brenner, “The Reported Human NADsyn2 is Ammonia-Dependent NAD+ synthetase from a Pseudomonad,” Journal of Biological Chemistry, v. 278, pp. 33056-33059 (2003). Download reprint
- C. Brenner, “Subtleties Among Subtilases: Structural Biology of Kex2 and Furin-Related Prohormone Convertases,”EMBO Reports, v. 4, pp. 937-938 (2003). Download reprint
- D.A. Kwasnicka, A. Krakowiak, C. Thacker, C. Brenner & S.R. Vincent, ” Coordinate Expression of NADPH-Dependent Flavin Reductase, FRE-1, and Hint-Related 7meGMP-Directed Hydrolase, DCS-1,” Journal of Biological Chemistry, v. 278, pp. 39051-39058 (2003). Download reprint
- A. Krakowiak, H.C. Pace, G. Michael Blackburn, M. Adams, A. Mekhalfia, R. Kaczmarek, J. Baraniak, W.J. Stec & C. Brenner, “Biochemical, Crystallographic and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors,” Journal of Biological Chemistry, v. 279, pp. 18711-18716 (2004). View Hint-N-ethylsulfamoyl adenosine at the Protein Data Bank. Download reprint
- C. Brenner, “Precariously on the Cusp of Oncogenomics,” chapter 1 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics poster the site at Wiley, or Amazon. Download book review in the New England Journal of Medicine.
- T.M. Maiolatesi & C. Brenner, “Chemical and Genetic Methods to Validate Targets in Non-Mammalian Organisms,” chapter 10 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomics poster, the site at Wiley, or Amazon. Download book review in the New England Journal of Medicine.
- P. Bieganowski & C. Brenner, “Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans,” Cell, v. 117, pp. 495-502 (2004). Download reprint
- P. Bieganowski, K. Shilinski, P.N. Tsichlis & C. Brenner, “Cdc123 and Checkpoint Forkhead Associated With RING Proteins Control the Cell Cycle By Controlling eIF2gamma Abundance, “Journal of Biological Chemistry,” v. 279, pp. 44656-44666 (2004). Download reprint
- C. Brenner, “Chemical Genomics in Yeast,” Genome Biology, v. 5, 240 (2004). Download reprint
- P.M. Clements, C. Breslin, E.D. Deeks, P.J. Byrd, L. Ju, P. Bieganowski, C. Brenner, M.-C. Moreira, A.M.R. Taylor & K.W. Caldecott, “The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4,” DNA Repair, v. 3, pp. 1493-1502 (2004). Download reprint
- K.P. Parks, H. Seidle, N. Wright, J.B. Sperry, P. Bieganowski, K. Howitz, D.L. Wright & C. Brenner, “Altered Specifity of Hint-W123Q Supports a Role for Hint Inhibition by Asw in Avian Sex Determination,” Physiological Genomics, v. 20, pp. 12-14 (2004). Download reprint and supplemental data
- T.-F. Chou, P. Bieganowski, K. Shilinski, J. Cheng, C. Brenner & C.R. Wagner, “31P NMR and Genetic Analysis Establish hinT as the only E. coli Purine Nucleoside Phosphoramidase and as Essential for Growth Under High Salt Conditions,” Journal of Biological Chemistry, v. 280, pp. 15356-15361 (2005). Download reprint and supplemental data
- H.F. Seidle, P. Bieganowski & C. Brenner, “Disease-Associated Mutations Inactivate AMP-Lysine Hydrolase Activity of Aprataxin,” Journal of Biological Chemistry, v. 280, pp. 20927-20931 (2005). View or download JBC Paper of the Week Summary. Download reprint and supplemental data
- C. Brenner, “Evolution of NAD Biosynthetic Enzymes,” Structure, v. 13, pp. 1239-1240 (2005). Download reprint
- K.L. Bogan & C. Brenner, “Fhit,” AfCS-Nature Molecule Pages (2006). DOI: 10.1038/mp.a000914.01.
- S.K. Milano, Y.-M. Kim, F.P. Stefano, J.L. Benovic & C. Brenner, “Nonvisual Arrestin Oligomerization and Cellular Localization are Regulated by Inositol Hexakisphosphate Binding,” Journal of Biological Chemistry, v. 281, pp. 9812-9823 (2006). View Arrestin-2-IP6 entry at the Protein Data Bank. Download reprint and supplemental data
- J. Martin, F. Magnino, K. Schmidt, A.-C. Piguet, J.-S. Lee, D. Semela, M.V. St-Pierre, A. Ziemiecki, D. Cassio, D. Mochly-Rosen, C. Brenner, S.S. Thorgeirsson & J.-F. Dufour, “Hint2, a Mitochondrial Apoptotic Sensitizer Downregulated in Hepatocellular Carcinoma,” Gastroenterology, v. 130, pp. 2179-2188 (2006). Download reprint
- P. Bieganowski, H.F. Seidle, M. Wojcik & C. Brenner, “Synthetic Lethal and Biochemical Analyses of NAD and NADH Kinases in Saccharomyces cerevisiae Establish Separation of Cellular Functions,” Journal of Biological Chemistry, v. 281, pp. 22439-22445 (2006). Download reprint
- A.B. Parsons, A. Lopez, I.E. Givoni, D.E. Williams, C.A. Gray, J. Porter, G. Chua, R. Sopko, R.L. Brost, C.-H. Ho, J. Wang, T. Ketela, C. Brenner, J.A. Brill, G.E. Fernandez, T.C. Lorenz, G.S. Payne, S. Ishihara, Y. Ohya, B. Andrews, T.R. Hughes, B.J. Frey, T.R. Graham, R.J. Andersen & C. Boone, “Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast,” Cell, v. 126, pp. 611-6255 (2006). Download reprint. Examine supplementary data.
- M. Wojcik, H.F. Seidle, P. Bieganowski & C. Brenner, “Glutamine-Dependent NAD+ synthetase: How a Two-Domain, Three-Substrate Enzyme Avoids Waste,” Journal of Biological Chemistry, v. 281, pp. 33395-33402 (2006). Download reprint
- P. Belenky, K.L. Bogan & C. Brenner, “NAD+ Metabolism in Health and Disease,” Trends in Biochemical Sciences, v. 32, pp. 12-19 (2007). Download reprint
- C.L. Linster, T.A. Gomez, K.C. Christensen, L.N. Adler, B.D. Young, C. Brenner & S.G. Clarke, “Arabidopis VTC2 Encodes GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants,” Journal of Biological Chemistry, v. 282, pp. 18879-18885 (2007). Download reprint. View JBC Paper of the Week Summary.
- P. Belenky, F.G. Racette, K.L. Bogan, J.M. McClure, J.S. Smith & C. Brenner, “Nicotinamide Riboside Promotes Sir2 Silencing and Extends Lifespan via Nrk and Urh1/Pnp1/Meu1 Pathways to NAD+,” Cell, v. 129, pp. 473-484 (2007). Download reprint and supplementary data. Read Leading Edge Preview in Cell, Research Highlights in Nature and Spotlight in ACS Chemical Biology.
- M.E. Robu, J.D. Larson, A. Nasevicius, S. Beiraghi, C. Brenner, S.A. Farber & S.C. Ekker, “p53 Activation by Knockdown Technologies,” PLOS Genetics, v. 3, issue 5, e78 (2007). Download reprint.
- C. Brenner, “Histidine Triad (HIT) Superfamily,” Encyclopedia of Life Sciences, (2007). John Wiley & Sons, Ltd: Chichester.
- W. Tempel, W.M. Rabeh, K.L. Bogan, P. Belenky, M. Wojcik, H.F. Seidle, L. Nedyalkova, T. Yang, A.A. Sauve, H.-W. Park & C. Brenner, “Nicotinamide Riboside Kinase Structures Reveal New Pathways to NAD+,” PLoS Biology, v. 5, issue 10, e263 (2007). View Nrk1-ADP, Nrk1-NR, Nrk1-AppNHp+NR, Nrk1-NMN, and Nrk1-tiazofurin entries at the Protein Data Bank. Download reprint and supporting information.
- R.S. Fuller, R.A. Bambara, T. Baker, B. Funnell, E. Wahle, M. O’Donnell, D. Kaiser, K. Skarstad, B. Konforti, S. Maki, T. Katayama, K. Sekimizu, J.H. Weiner, R.W. Davis, L. Rowen, M.F. Goodman, J. Spudich, S. Pfeffer, C.C. Richardson, P. Polaczek, R. Calendar, R. Kolodner, J. Griffith, B. Stillman, P. Modrich, C. Brenner & C. Yanofsky, “A Tribute to Arthur Kornberg, 1918-2007,” Nature Structural & Molecular Biology, v. 15, pp. 2-17 (2008). Download reprint
- G.L. Loring, K.C. Christensen, S.A. Gerber & C. Brenner, “Yeast Chfr Homologs Retard Cell Cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-Dependent Ubiquitination,” Cell Cycle, v. 7, pp. 95-105 (2008). Download reprint and supplementary data
- P.A. Belenky, T.G. Mogu & C. Brenner, “S. cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter, Nrt1,” Journal of Biological Chemistry, v. 283, pp. 8075-8079 (2008). Download reprint and supplementary data
- K.L. Bogan & C. Brenner, “Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition,” Ann Review Nutrition, v. 28, pp. 115-130 (2008). Download reprint
- C.L. Linster, L.T. Adler, K. Webb, K.C. Christensen, C. Brenner & S.G. Clarke, “A Second GDP-L-Galactose Phosphorylase in Arabidopsis en Route to Vitamin C: Covalent Intermediate and Substrate Requirements for the Conserved Reaction,” Journal of Biological Chemistry, v. 283, pp. 18483-18492 (2008). Download reprint
- L. Brooks,III, E.G. Heimsath, Jr., G.L. Loring & C. Brenner, “FHA-RING Ubiquitin Ligases in Cell Division Cycle Control,” Cellular and Molecular Life Sciences, v. 65, cover and pp. 3458-3466 (2008). Download reprint
- P. Belenky, K.C. Christensen, F. Gazzaniga, A.A. Pletnev & C. Brenner, “Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism,” Journal of Biological Chemistry, v. 284, pp. 158-164 (2009). Download reprint
- P. Bieganowski & C. Brenner, “Nicotinamide Riboside Kinase Compositions and Methods for Using the Same,” Australian Patent 2005211773, issued June 1, 2009.
- F. Gazzaniga, R. Stebbins, S. Z. Chang, M.A. McPeek & C.Brenner, “Microbial NAD Metabolism: Lessons from Comparative Genomics, “Microbiology and Molecular Biology Reviews, v. 73, pp. 529-541 (2009). Download reprint
- K.L. Bogan, C. Evans, P. Belenky, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, ” Identification of Isn1 and Sdt1 as Glucose and Vitamin-regulated NMN and NaMN 5′-nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside,” Journal of Biological Chemistry, v. 284, pp. 34861-34869 (2009). Download reprint and supplementary data
- C. Evans, K.L. Bogan, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, “NAD+ Metabolite Levels as a Function of Vitamins and Calorie Restriction: Evidence for Different Mechanisms of Longevity,” BMC Chemical Biology, v. 10, 2 (2010). Download reprint and supplementary data
- K.L. Bogan & C. Brenner, “5′-Nucleotidases and their New Roles in NAD+ and Phosphate Metabolism,” New Journal of Chemistry, v. 34, pp. 845-853 (2010). Download reprint
- F. Syeda, R.L. Fagan, M. Wean, G.V. Awakumov, J.R. Walker, S. Xue, S. Dhe-Paganon & C. Brenner, “The RFTS Domain is a DNA-Competitive Ingibitor of Dnmt1,” Journal of Biological Chemistry, v. 286, pp. 15344-15351 ( 2011). Download reprint
- C. Brenner. “On the Nonspecific Degradation of NAD+ to Nicotinamide Riboside,” Journal of Biological Chemistry, v. 286, p. le5 (2011). Download reprint
- P. Belenky, R. Stebbins, K.L. Bogan, C.R. Evans & C. Brenner, “Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production,” PLoS ONE, v. 6, p. e19710 (2011). Download reprint
- J. Boylston & C. Brenner, “FHIT,” Encyclopedia of Signaling Molecules, S. Choi, ed, chapter 68, part 7, pp. 613-616 (2012). DOI: 10.1007/978-1-4419-0461-4_68. Download reprint
- C. Brenner, P. Belenky & K.L. Bogan, “Yeast Strain and Method for Using the Same to Produce Nicotinamide Riboside,” US Patent 8,114,626, issued February 14, 2012. Download reprint
- C. Brenner & D. Ringe, “Response to the New MCAT: ASBMB Premedical Curriculum,” American Society for Biochemistry and Molecular Biology, v. 11, pp. 12-14 (2012). Download reprint
- R.R. Midtkandal, P. Redpath, S.A.J. Trammell, S.J.F. Macdonald, C. Brenner & M.E. Migaud, “Novel synthetic route to the C-nucleoside, 2-deoxy benzamide riboside,” Bioorganic & Medicinal Chemistry Letters v. 22, pp. 5204-7 (2012). Download reprint
- C. Brenner, “Nicotinamide riboside kinase compositions and methods for using the same,” US Patent 8,197,807, issued June 12, 2012. Download reprint
- C. Brenner, “Changes in Chemistry and Biochemistry Education: Creative Responses to MCAT Revisions in the Age of the Genome,” Biochemistry and Molecular Biology Education, v. 41, pp. 1-4 (2013). Download reprint
- C. Brenner, “Nicotinamide riboside kinase compositions and methods for using the same,” US Patent 8,383,086, issued February 26, 2013. Download reprint
- K.L. Bogan & C. Brenner, “Biochemistry: Niacin/NAD(P),” Encyclopedia of Biological Chemistry, W.J. Lennarz & M.D. Lane, v. 3, pp.172-178, (2013). Waltham, MA: Academic Press. Download reprint
- S.A.J. Trammell & C. Brenner, “Targeted, LCMC-Based Metabolomics for Quantitative Measurement of NAD+ Metabolites,” Computational and Structural Biotechnology Journal, v. 4, e201301012 (2013). DOI: 10.5936/csbj.201301012. Download reprint.
- C. Brenner, “Rethinking Premedical and Health Professional Curricula in Light of MCAT 2015,” Journal of Chemical Education, v. 90, pp. 807-812 (2013). DOI:10.1021/ed4002738. Download reprint
- R.L. Fagan, D.E. Cryderman, L. Kopelovich, L.L. Wallrath & C. Brenner, “Laccaic Acid A is a Direct, DNA-Competitive Inhibitor of DNA Methyltransferase 1,” Journal of Biomedical Chemistry, v.288, pp. 23858-23867 (2013). DOI: 10.1074/jbc.M113.480517. Download reprint.
- C. Brenner, “Demystifying the Chalk Talk,” American Society for Biochemistry and Molecular Biology, v. 12, pp. 33-35 (2013). Download reprint
- S. Ghanta, R.E. Grossmann & C. Brenner, “Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications” Critical Reviews in Biochemistry and Molecular Biology, v. 48, pp. 561-574 (2013). Download reprint.
- P.J. Kennelly, J.S. Bond, B.S. Masters, E.A. Dennis, C. Brenner & D.M. Raben, “Desperately Seeking Flexner: Time to Reemphasize Basic Science in Medical Education” Academic Medicine, v. 88, pp. 1405-1406 (2013). DOI: 10.1097/ACM.0b013e3182a225be. Download reprint
- R.L. Fagan, M. Wu, F. Chédin & C. Brenner, “An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-targeted Molecular Probes” PLoS One, v. 11, e78752 (2013). Download reprint.
- S-C. Mei & C. Brenner, “NAD as a Genotype-Specific Drug Target” Chemistry & Biology, v. 20, pp. 1307-1308 (2013). Download reprint
- J. Huang, A. Stewart, B. Maity, J. Hagen, R.L. Fagan, J. Yang, D.E. Quelle, C. Brenner & R.A. Fisher, “RGS6 Suppresses Ras-inducded Cellular Transformation by Facilitating Tip60-mediated Dnmt1 Degradation and Promoting Apoptosis,” Oncogene, v. 33, pp. 3604-11 (2014). DOI:10.1038/onc.2013.324. Download reprint
- C. Brenner, “Understanding Faculty Salaries,” American Society for Biochemistry and Molecular Biology, v. 13, pp. 28-29 (2014). Download reprint
- C. Brenner, “Metabolism: Targeting a fat-accumulation gene” Nature, v. 508, pp. 194-195 (2014). DOI: 10.1038/508194a. Download reprint.
- C. Brenner, “Histidine Triad Superfamily” Encyclopedia of Life Sciences, John Wiley & Sons Ltd: Chichester (2014). DOI: 10.1002/9780470015902.a0020545.pub2.
- J.A. Boylston & C. Brenner, “A Knockdown with Smoke Model Reveals Fhit as a Repressor of Heme Oxygenase 1,” Cell Cycle, v. 13, pp. 2913-30 (2014). DOI:10.4161/15384101.2014.946858. Download reprint
- B.-K. Wu, S.-C. Mei & C. Brenner, “RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation,” Cell Cycle, v. 13, pp. 3222-3231 (2014). DOI:10.4161/15384101.2014.950886. Download reprint
- S.-C. Mei & C. Brenner, “Quantification of Protein Copy Number in Yeast: the NAD+ Metabolome,” PLoS One v. 9, e106496 (2014). DOI: 10.1371/journal.pone.0106496. Download reprint
- B.-K. Wu & C. Brenner, “Suppression of TET1-Dependent DNA Demethylation is Essential for KRAS-Mediated Transformation,” Cell Reports, v. 9, pp. 1827-1840 (2014). DOI: 10.1016/j.celrep.2014.10.063. Download reprint
- C. Brenner, “Boosting NAD to Spare Hearing,” Cell Metabolism, v. 21, pp.926-927 (2014). DOI: 10.1016/j.cmet.2014.11.015. Download reprint.
- S.-C. Mei & C. Brenner, “Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous,” PLoS Biology, v. 13, e1002048 (2015). Download reprint
- S.A.J. Trammell & C. Brenner, “NNMT: A Bad Actor in Fat Makes Good in Liver,” Cell Metabolism, v. 22, pp. 200-201 (2015). DOI: 10.1016/j.cmet.2015.07.017. Download reprint
- S.A.J. Trammell, L. Yu, P. Redpath, M.E. Migaud & C. Brenner, “Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk,” The Journal of Nutrition, v. 146, pp. 957-963 (2016). DOI: 10.3945/jn.116.230078. Download reprint
- S.A.J. Trammell, B.J.Weidemann, A.Chadda, M.S. Yorek, A. Holmes, L.J.Coppey, A. Obrosov, R.H. Kardon, M.A. Yorek & C. Brenner, “Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice,” Scientific Reports, v. 6, 26933 (2016). DOI: 10.1038/srep26933. Download reprint
- S.A.J Trammell, M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud & C. Brenner, “Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.” Nature Communications, v. 7, pp. 12948 (2016). DOI: 10.1038/ncomms12948. Download reprint
- J. Ratajczak, M. Joffraud, S.A.J. Trammell, R. Ras, N. Canela, M. Boutant, S.S. Kulkarni, M. Rodrigues, P. Redpath, M.E. Migaud, J. Auwerx, O. Yanes, C. Brenner & C. Canto, “NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.” Nature Communications, v. 7, 13103 (2016). DOI: 10.1038/ncomms13103. Download reprint.
- J.L. Wilsbacher, M. Cheng, D. Cheng, S.A.J. Trammell, Y. Shi, J. Guo, S.L. Koeniger, P.J. Kovar, Y. He, S. Jagadeeswaran, H.R. Heyman, B.K. Sorensen, R.F. Clark, T.M. Hansen, K.L. Longenecker, D. Raich, A.V. Korepanova, D.L. Towne, V.C. Abraham, H. Tang, S.M. McLoughlin, M.L. Curtin, M.R. Michaelides, D. Maag, F.G. Buchanan, W. Gao, S.H. Rosenberg, C. Brenner & C. Tse, “Discovery and Characterization of Novel, Orally Bioavailable Non-substrate and Substrate NAMPT Inhibitors,” Molecular Cancer Therapeutics, v. 16, pp. 1236-1245 (2017). DOI: 10.1158/1535-7163.MCT-16-0819. Download reprint.
- M.V. Hamity, S.R. White, R.Y. Walder, M.S. Schmidt, C. Brenner & D.L. Hammond, “Nicotinamide Riboside, a Form of Vitamin B3 and NAD+ Precursor, Relieves the Nociceptive and Aversive Dimensions of Paclitaxel-induced Peripheral Neuropathy in Female Rats,” Pain, v. 158, pp. 962–972 (2017). DOI: 10.1097/j.pain.0000000000000862. Download reprint.
- R. Fletcher, J. Ratajczak, C.L. Doig, L.A. Oakey, R.Callingham, G. da Silva Xavier, A. Garten, Y.S. Elhassan, P. Redpath, M.E. Migaud, A. Philp, C. Brenner, C. Canto & G.G. Lavery, “Nicotinamide Riboside Kinases Display Redundancy in Mediating Nicotinamide Mononucleotide and Nicotinamide Riboside Metabolism in Skeletal Muscle Cells,” Molecular Metabolism, v. 6 (2017). DOI: 10.1016/j.molmet.2017.05.011. Download reprint.
- P. Vaur, B. Brugg, M. Mericskay, Z. Li, M.S. Schmidt, D. Vivien, C. Orset, E. Jacotot, C. Brenner & E. Duplus, “Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration,” FASEB Journal (2017). DOI: 10.1096/fj.201700221RR. Download reprint.
- S.Thakur & C. Brenner, “KRAS-driven miR-29b Expression is Required for Tumor Suppressor Gene Silencing,” Oncotarget, v.8(43), pp. 74755-74766 (2017). DOI: 10.18632/oncotarget.20364. Download reprint.
- S. Sato, G. Solanas, F.O. Peixoto, L. Bee, A. Symeonidi, M.S. Schmidt, C. Brenner, S. Masri, S.A. Benitah & P. Sassone-Corsi, “Circadian Reprogramming Identifies Metabolic Pathways of Aging,” Cell, v. 170(4), pp. 664-677 (2017). DOI: 10.1016/j.cell.2017.07.042. Download reprint.
- N. Diguet, S.A.J. Trammell, C. Tannous, R. Deloux, J. Piquereau, N. Mougenot, A. Gouge, M. Gressette, B. Manoury, J. Blanc, M. Breton, J.F. Decaux, G. Lavery, I. Baczkó, J. Zoll, A. Garnier, Z. Li, C. Brenner & M. Mericskay, “Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy,” Circulation, v. 137(21), pp. 2256-2273 (2018). DOI: 10.1161/CIRCULATIONAHA.116.026099. Download reprint. Read accompany commentary
- Fangmann, E.M. Theismann, K. Türk, D.M. Schulte, I. Relling, K. Hartmann, J.K. Keppler, J.R. Knipp, A. Rehman, F.A. Heinsen, A. Franke, L. Lenk, S. Freitag-Wolf, E. Appel, S. Gorb, C. Brenner, D. Seegert, G.H. Waetzig, P. Rosenstiel, S. Schreiber, K. Schwarz & M. Laudes, “Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans,” Diabetes Care, v. 41(3), pp. 398-405 (2018). DOI: 10.2337/dc17-1967. Download reprint.
- D.S. Matasic, C. Brenner & B. London, “Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease,” American Journal of Physiology, v. 314(4), pp. H839-H852 (2018). DOI: 10.1152/ajpheart.00409.2017. Download reprint.
- O.L. Dollerup, B.Christensen, M. Svart, M.S. Schmidt, K. Sulek, S. Ringgaard, H. Stødkilde-Jørgensen, N. Møller, C. Brenner, J.T. Treebak &N. Jessen, “A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects,” Journal of Clinical Nutrition, v.108(2), pp. 343-353 (2018). DOI: 10.1093/ajcn/nqy132. Download reprint.
- S.J. Mitchell, M. Bernier, M.A. Aon, S. Cortassa, E.Y. Kim, E.F. Fang, H.H. Palacios, Ali A1, I. Navas-Enamorado, A. Di Francesco, T.A. Kaiser, T.B. Waltz, N. Zhang, J.L. Ellis, P.J. Elliott, D.W. Frederick, V.A. Bohr, M. S. Schmidt, C. Brenner, D.A. Sinclair, A. A. Sauve, J.A. Baur & R. de Cabo, “Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice,” Cell Metabolism, v. 27(3):667-676.e4 (2018). DOI: 10.1016/j.cmet.2018.02.001. Download reprint.
- H.W. Liu, C.B. Smith, M.S. Schmidt, X.A. Cambronne, M.S. Cohen, M.E. Migaud, C. Brenner & R.H. Goodman, “Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration,” Proceedings of the National Academy of Sciences, v.115 (42), pp. 10654-10659 (2018). DOI: 10.1073/pnas.1809392115. Download reprint
- C. Brenner & A.C. Boileau, “Pterostilbene Raises Low Density Lipoprotein Cholesterol in People,” Clinical Nutrition. v.38(1), pp.480-481 (2019). DOI: 10.1016/j.clnu.2018.10.007. Download reprint.
- P. H. Ear, A. Chadda, S. B. Gumusoglu, M. S. Schmidt, S. Vogeler, J. Malicoat, J. Kadel, M. M. Moore, M. E. Migaud, H. E. Stevens & C. Brenner, “Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring,” Cell Reports. v. 26 (4), pp. 969-983 (2019). DOI: 10.1016/j.celrep.2019.01.007. Download reprint.
- W. Shi, M.A. Hegeman, A. Doncheva, I. van der Stelt, M. Bekkenkamp-Grovenstein, E. M. van Schothorst, C.Brenner, V. C. J. de Boer & J. Keijer, “Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3,” Molecular Nutrition & Food Research, v. (2019). DOI: 10.1002/mnfr.201801100. Download reprint
- D. Conze, C. Brenner, & C.L. Kruger, “Safety and Metabolism of Long-Term Administration of Niagen (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults,” Scientific Reports, v. 9, 9772 (2019). DOI: 10.1038/s41598-019-46120-z. Download reprint
- M.S. Schmidt, & C. Brenner, “Absence of evidence that Slc12a8 Encodes a Nicotinamide Mononucleotide Transporter,” Nature Metabolism, v. 1, pp. 660-661 (2019). DOI: 10.1038/s42255-019-0085-0. Download reprint
- Y.S. Elhassan, K. Kluckova, R.S. Fletcher, M.S. Schmidt, A. Garten, C.L. Doig, D.M. Cartwright, L. Oakey, C.V. Burley, N Jenkinson, M. Wilson, S.J.E. Lucas, I. Akerman, A. Seabright, Y.C. Lai, D.A. Tennant, P. Nightingale, G.A. Wallis, K.N. Manolopoulos, C. Brenner, A. Philip, G.G. Lavery, “Nicotinamide Riboside Augments the Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic ad Anti-inflammatory Signatures in Aged Subjects: a Placebo-controlled, Randomized Trial,” Cell Reports, v. 28, 7 (2019). DOI: 10.1016/j.celrep.2019.07.043. Download reprint
- C. Brenner, “Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution,” Journal of Experimental Neuroscience v. 13, pp. 1-3 (2019). DOI: 10.1177/1179069519869679. Download reprint
- N.R. Fons, R.K. Sundaram, G.A. Breuer, S. Peng, R.L. McLean, A.N. Kalathil, M.S. Schmidt, D.M. Carvalho, A. Mackay, C. Jones, A.M. Carcaboso, J. Nazarian, M.E. Berens, C. Brenner, & R.S. Bindra., “PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma,” Nature Communications, v. 10, 3790 (2019). DOI: 10.1038/s41467-019-11732-6. Download reprint
- D.S. Matasic, J-T. Yoon, H. Mehdi, J.M. McLendon, M.S. Schmidt, A.M. Greiner, P. Quinones, G.M. Morgan, R. Bourdreau, K. Irani, C. Brenner & B. London., “Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors,” Journal of Molecular and Cellular Cardiology., Journal of Molecular and Cellular Cardiology, v. 141, pp. 70-81, (2020). DOI: 10.1016/j.yjmcc.2020.01.013 Download reprint
- E. Pirinen, M. Auranen, N. Khan, V. Brilhante, N. Urho, A. Pessia, A. Hakkarainen, J. Kuula, U. Heinonen, M.S. Schmidt, K. Haimilahti, P. Piirila, N. Lundbom, M.R. Taskinen, C. Brenner, V. Velagapudi, K. Pietilainen & A. Suomalainen, “Niacin Cures Systematic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy,” Cell Metabolism, v. 31, pp. 1078-1090 (2020). DOI: 10.1016/j.cmet.2020.04.008 Download reprint
- D.C. Levine, H. Hong, K.M. Ramsey, A.H. Affinati, M.S. Schmidt, J. Cedernaes, C. Omura, C. Lee, C. Brenner, C.B. Peek & J. Bass. “NAD+ Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging,” Molecular Cell, v. 78 pp. 835-849, (2020). DOI: 10.1016/j.molcel.2020.04.010 Download reprint
- N.T. Fluharty & C. Brenner, “Fat Mobilization Without Weight Loss is a Potentially Rapid Response to Nicotinamide Riboside in Obese People: It’s Time to Test with Exercise,” American Journal of Clinical Nutrition, v, 112, pp. 243-244 (2020). DOI: 10.1093/ajcn/nqaa109 Download reprint
- C.D. Heer & C. Brenner, “Letting off Electrons to Cope with Metabolic Stress,” Nature Metabolism, v. 2, pp. 485-486, (2020). DOI: 10.1038/s42255-020-0207-8 Download reprint
- R. Parker, M.S. Schmidt, O. Cain, B. Gunson & C. Brenner, “The NAD+ Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease,” Hepatology Communications, v. 4, pp.1183-1192 (2020). DOI: 10.1002/hep4.1530 Download reprint
- M. Gerasimenko, S. Cherepanov, K. Furuhara, O. Lopatina, A. Salmina, A. Shabalova, C. Tsuji, S. Yokoyama, K. Ishihara, C. Brenner & H. Higashida, “Nicotinamide Riboside Supplementation Corrects the Deficits in Oxytocin, Sociability and Anxiety of CD157 Mutants in a Mouse Model of Autism Spectrum Disorder,” Scientific Reports, v. 10, 10035, (2020). DOI: 10.1038/s41598-019-57236-7 Download reprint
- B.C. Gilmour, R. Gudmundsrud, J. Frank, A. Hov, S. Lautrup, Y. Aman, H. Røsjø, C. Brenner, M. Ziegler, O.B. Tysnes, C. Tzoulis, T. Omland, A. Søraas, T. Holmøy, L.H. Bergersen, J. Storm-Mathisen, H. Nilsen & E.F. Fang, “Targeting NAD+ in Translational Research to Relieve Diseases and Conditions of Metabolic Stress and Ageing,” Mechanisms of Ageing and Development, v.186, 111208 (2020). DOI: 10.1016/j.mad.2020. Download reprint
- T.S. Nam, D.R. Park, S.-Y. Rah, T.G. Woo, H.T. Chung, C. Brenner & U.-H. Kim. “Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration” FASEB Journal, v.34, pp. 12565-12576 (2020). DOI: 10.1101/2020.03.24.004739 Download reprint
- X. Zhang, N.F. Henneman, P.E. Girardot, J.T. Sellers, M.A. Chrenek, Y. Li, J.Wang, C.Brenner, J.M. Nickerson & J.H. Boatright, “Systemic Treatment with Nicotinamide Riboside is Protective in a Mouse Model of Light-Induced Retinal Degeneration” Investigative Ophthalmology & Visual Science, v.61, 47 (2020). DOI: 10.1167/iovs.61.10.47 Download reprint
- C.D. Heer, D.J. Sanderson, L.S. Voth, Y M.O. Alhammad, M.S. Schmit, S.A.J. Trammell, S. Perlan, M.S. Cohen, A.R. Fehr & C. Brenner “Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity” Journal of Biological Chemistry, v. 295, pp. 17986-17996 (2020). DOI: 10.1074/jbc.RA120.015138 Download reprint
- Y. Takaso, M. Noda, T. Hattori, J. Roboon, M. Hatano, H. Sugimoto, C. Brenner, Y. Yamamoto, H. Okamoto, H. Higashida, M. Ito, T. T. Yoshizaki & O. Hori, “Deletion of CD38 and Supplementation of NAD+ Attenuate Axon Degeneration in a Mouse Facial Nerve Axotomy Model,” Scientific Reports, v.10, 17795, (2020). DOI: 10.1038/s41598-020-73984-3 Download reprint
- A.J. Covarrubias, A. Kale, R. Perrone, J.A. Lopez-Dominguez, A.O. Pisco, H.G. Kassler, M.S. Schmidt, I. Heckenbach, R. Kwok, C.D. Wiley, H.S Wong, I.J. Kim, E. Silva, K. Vitangcol, K.O. Shin, Y.M. Lee, R. Riley, I. Ben-Sahra, M. Ott, B. Schilling. M. Scheibye-Knudsen, K. Ishihara, S.R. Quake, J. Newman, C. Brenner, J. Campis & E. Verdin, “Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages,” Nature Metabolism, v. 2, pp. 1265-1283, (2020). DOI: 10.1038/s42255-020-00305-3 Download reprint
- R. Ghugari, S. Tsao, M. Schmidt, E. Bonneil, C. Brenner & A. Verreault “Mechanisms to Reduce the Cytotoxicity of Pharmacological Nicotinamide Concentrations in the Pathogenic Fungus Candida Albicans,” FEBS Journal, v. 288, pp. 3478-3506 (2021). DOI: 10.1111/febs.15687 Download reprint
- J. Roboon, T. Hattori. H. Ishii, M. Takarada-Iemata. D.T. Nguyen, C.D. Heer, D. O’Meally, C. Brenner, Y. Yamomoto, H. Okamoto, H. Higashida, & O. Hori, “Inhibition of CD38 and supplementation of nicotinamide riboside ameliorate lipopolysaccharide-induced microglial and astrocytic neuroinflammation by increasing NAD+,” Journal of the International Society for Neurochemistry, v. 158, pp. 311-327, (2021). DOI: 10.111/jnc.15367 Download reprint
- C.Brenner, Comment on “Nicotinamide mononucleotide increases muscle insulin sensitivity in prediabetic women”, Science, v.373, (2021). DOI: 10.1123/science.abj1696 reprint
- X. Zhang, N. Zhang, M.A. Chrenek, P.E. Girardot, J. Wang, J.T. Sellers, E.E. Geisert, C. Brenner, J.M. Nickerson, J.H. Boatright & Y. Li, ” Systemic treatment with nicotinamide riboside is protective in two mouse models of retinal ganglion cell damage,” Pharmaceutics, v. 13, 893, (2021). DOI: 10.3390/pharmaceutics13060893 reprint
- C.Brenner, “Viral infection as an NAD+ battlefield,” Nature Metabolism, v. 4, 2-3 (2022). DOI: 10.1038/s42255-021-00507-3 reprint
- J. Wu, K. Singh, A. Lin, A.M. Meadows, K.Wu, V. Shing, M. Bley, S. Hassanzadeh, R.D. Huffstutler, M.S. Schmidt, L.P. Blanco, R. Tian, C. Brenner,M. Pirooznia, M.J. Kaplan, & M.N. Sack, “Boosting NAD+ blunts TLR4-induced type I IFN in control and systemic lupus erythematosus monocytes,” The Journal of Clinical Investigation, v. 132, (2022). DOI: 10.1172/JCI139828 reprint
- J.-Y. Yoon, N. Daneshgar, Y. Chu, B. Chen, M. Hefti, A. Vikram, K. Irani, L.-S. Song, C. Brenner, E. D. Abel, B. London, D.-F. Dai, “Metabolic rescue ameliorates mitochondrial encephalo-cardiomyopathy in murine and human iPSC models of Leigh syndrome”, Wiley Online Library, v. 12, (2022). DOI: 10.1002/ctm2.954 reprint
- C.Brenner, “Sirtuins are Not Conserved Longevity Genes”, Life Metabolism, v.1, in press (2022). DOI: 10.1093/lifemeta/loac025 preprint
- C.Brenner, “Longevity Lessons”, Science, v. 377, p. 718 (2022). DOI: 10.1126/science.add9130 reprint
- C.Brenner, “A Science-Based Review of the World’s Best-Selling Book on Aging”, Archives of Gerontology and Geriatrics, v. 104, 104825 (2023). DOI: 10.1016/j.archger.2022.104825 reprint
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