1983-1985 Research Associate for Anthony J. Brake Chiron Corporation, Emeryville, CA
1986-1988 Research Associate for Kunihiro Matsumoto DNAX Research Institute, Palo Alto, CA
1996-2000 Assistant Professor of Microbiology & Immunology Jefferson Medical College Member, Program in Structural Biology, Kimmel Cancer Center
2000-2003 Associate Professor of Microbiology & Immunology Jefferson Medical College Director, Structural Biology & Bioinformatics Program, Kimmel Cancer Center Thomas Jefferson University, Philadelphia, PA
2003-2007 Associate Professor of Genetics and of Biochemistry Dartmouth Medical School
2003-2008 Director, Cancer Mechanisms Program Norris Cotton Cancer Center
2005-2009 Scientific Director Comprehensive Thoracic Oncology Program Dartmouth-Hitchcock Medical Center
2007-2009 Professor of Genetics and of Biochemistry Dartmouth Medical School
2008-2009 Associate Director for Basic Sciences Norris Cotton Cancer Center, Lebanon, NH
2009-2020 Professor and DEO of Biochemistry Carver College of Medicine University of Iowa, Iowa City, IA
2010-2020 Professor of Internal Medicine and Roy J. Carver Chair in Biochemistry Carver College of Medicine University of Iowa, Iowa City, IA
2011-2020 Founding Co-Director, Obesity Research and Education Initiative Office of the Provost University of Iowa, Iowa City, IA
1979-1980 Connecticut State Scholar
1979-1983 National Merit Scholar
1988-1992 Program in Cancer Biology trainee of the NCI
1999-2003 Yeast Cell Cycle and Cell Cycle Checkpoints section of GE636
2004-2009 NAD+ Metabolism section of the MCB Core Course
2005-2008 Genetics 144, Oncogenomics
2005-2007 Yeast Genetics section of the MCB Core Course
2010-2018 Carbohydrate Metabolism Section of BIOC:3120
2019-2020 Lipid and nucleotide metabolism section of BIOC:3130
Brake, C. Brenner, R. Najarian, P. Laybourn & J. Merryweather, “Structure of Genes Encoding Precursors of the Yeast Peptide Mating Pheromone a-Factor” in Protein Transport and Secretion, M. J. Gething, ed., pp. 103-108 (1985). Download reprint
I. Miyajima, M. Nakafuku, N. Nakayama, C. Brenner, A. Miyajima, K. Kaibuchi, K. Arai, Y. Kaziro & K. Matsumoto, “GPA1, A Haploid-Specific Essential Gene, Encodes a Yeast Homolog of Mammalian G Protein Which May Be Involved in Mating Factor Signal Transduction,” Cell, v. 50, pp. 1011-1019 (1987). Download reprint
C. Brenner, N. Nakayama, M. Goebl, K. Tanaka, A. Toh-e & K. Matsumoto, “CDC33 Encodes mRNA Cap-Binding Protein eIF-4E of Saccharomyces cerevisiae,” Mol Cell Biol, v. 8, pp. 3556-3559 (1988). Download reprint
K. Matsumoto, M. Nakafuku, N. Nakayama, I. Miyajima, K. Kaibuchi, A. Miyajima, C. Brenner, K. Arai & Y. Kaziro, “The Role of G Proteins in Yeast Signal Transduction,” Cold Spring Harbor Symp Quant Biol, v. 53, pp. 567-575 (1988). Download reprint
R.S. Fuller, C. Brenner, P. Gluschankof & C.A. Wilcox, “The Yeast Prohormone-Processing Kex2 Protease, an Enzyme with Specificity for Paired Basic Residues,” in Methods in Protein SequenceAnalysis, Jornvall, H., Hoog, J.-O. & Gustavsson, A.-M., pp. 205-214 (1991). Download reprint
C. Brenner & R.S. Fuller, “Structural and Enzymatic Characterization of a Purified Prohormone-Processing Enzyme: Secreted, Soluble Kex2 Protease,” Proc Natl Acad Sci, v. 89, pp. 922-926 (1992). Download reprint
H. Angliker, P. Wikstrom, E. Shaw, C. Brenner & R.S. Fuller, “The Synthesis of Inhibitors of Processing Proteases and Their Action on the Kex2 Protease of Yeast,” Biochem J, v. 293, pp. 75-81 (1993). Download reprint
C. Brenner, A. Bevan & R.S. Fuller, “One-Step Site-Directed Mutagenesis of The Kex2 Protease Oxyanion Hole,”Current Biology, v. 3, pp. 498-506 (1993). Download reprint
C. Brenner, A. Bevan & R. S. Fuller, “Methods for Analyzing the Specificity and Activity of a Prohormone-Processing Enzyme, the Yeast Kex2 Protease (Kexin),” Meth Enz, v. 244, pp. 152-167 (1994). Download reprint
C. Brenner, “Reducing the Energy Barrier to Crystallization, review of Crystallization of Nucleic Acids and Proteins,”Protein Science, v. 3, pp. 2471-2472 (1994). Download reprint
H. Diefenbach-Jagger, C. Brenner, B.E. Kemp, W. Baron, J. McLean, T.J. Martin & J.M. Moseley, “Arg21 is the Preferred Kexin Cleavage Site in Parathyroid-Hormone-Related Protein,” Eur J Biochem, v. 229, pp. 91-98 (1995). Download reprint
C. Brenner, H.C. Pace, P.N. Garrison, A.K. Robinson, A. Rosler, X.H. Liu, G.M. Blackburn, C.M. Croce, K. Huebner & L.D. Barnes, “Purification and Crystallization of Complexes Modeling the Active State of the Fragile Histidine Triad Protein,” Protein Engineering, v. 10, pp. 1461-1463 (1997). Download reprint
G.M. Blackburn, X. Liu, A. Rosler & C. Brenner, “Two Hydrolase Resistant Analogues of Diadenosine 5′,5”’-P1,P3-triphosphate for Studies with Fhit, the Human Fragile Histidine Triad Protein,” Nucleosides and Nucleotides, v. 17, pp. 301-308 (1998). Download reprint
H.C. Pace, P.N. Garrison, A.K. Robinson, L.D. Barnes, A. Draganescu, A. Rosler, G.M. Blackburn, Z. Siprashvili, C.M. Croce, K. Huebner & C. Brenner, “Genetic, Biochemical and Crystallographic Characterization of Fhit-Substrate Complexes as the Active Signaling Form of Fhit,” Proc Natl Acad Sci, v. 95, pp. 5484-5489 (1998). View Fhit-IB2, Fhit H96N-IB2 entries at the Protein Data Bank. Download reprint
Y. Pekarsky, M. Campiglio, Z. Siprashvili, T. Druck, Y. Sedkov, S. Tillib, A. Draganescu, P. Wermuth, J.H. Rothman, K. Huebner, A.M. Buchberg, A. Mazo, C. Brenner & C.M. Croce, “Nitrilase and Fhit Homologs are Encoded as Fusion Proteins in Drosophila melanogaster and Caenorhabditis elegans,” Proc Natl Acad Sci, v. 95, pp. 8744-8749 (1998). Download reprint
A. Bevan, C. Brenner & R.S. Fuller, “Quantitative Assessment of Enzyme Specificity in vivo: P2 Recognition by Kex2 Protease Defined in a Genetic System,” Proc Natl Acad Sci, v. 95, pp. 10384-10389 (1998). Download reprint
X. Liu, C. Brenner, A. Guranowski, E. Starzynska & G.M. Blackburn, “New Tripodal, ‘Supercharged Analogs’ of Adenosine Nucleotides: Inhibitors for the Fhit Ap3A Hydrolase,” Angew Chem Int Ed, v. 38, pp. 1244-1247 (1999). Download reprint
K. Huebner, G. Sozzi, C. Brenner, M.A. Pierotti & C.M. Croce, “Fhit Loss in Lung Cancer: Diagnostic and Therapeutic Implications,” Advances in Oncology, v. 15, pp. 3-10 (1999). Download reprint
M.J. Fernandes, A.A. Finnegan, L.D. Siracusa, C. Brenner, N.N. Iscove & B. Calabretta, “Characterization of a Novel Receptor that Maps Near the Natural Killer Gene Complex: Demonstration of Carbohydrate Binding and Expression in Hematopoietic Cells,” Cancer Research, v. 59, pp. 2709-2717 (1999). Download reprint
C. Brenner, P. Bieganowski, H.C. Pace & K. Huebner, “The Histidine Triad Superfamily of Nucleotide-Binding Proteins,” J Cellular Physiology, v. 181, pp. 179-187 (1999). Download reprint. Please see ref. 38 for the most current review on HIT proteins.
A. Draganescu, S.C. Hodawadekar, K.R. Gee & C. Brenner, “Fhit-Nucleotide Specificity Probed with Novel Fluorescent and Fluorogenic Substrates,” J Biol Chem, v. 275, pp. 4555-4560 (2000). Download reprint The reagents can be ordered from Molecular Probes, Inc.
C. Brenner, “A Cultivated Taste for Yeast,” Genome Biology, v. 1, pp. reviews103.1-103.4 (2000). Download reprint
C. Brenner, “Fhitness and Cancer in the Mouse,” Trends in Genetics, v. 16, p. 294 (2000). Download reprint
H.C. Pace, S.C. Hodawadekar, A. Draganescu, J. Huang, P. Bieganowski, Y. Pekarsky, C.M. Croce & C. Brenner, “Crystal Structure of the Worm NitFhit Rosetta Stone Protein Reveals a Nit Tetramer Binding Two Fhit Dimers,” Current Biology, v. 10, pp. 607-617 (2000). View NitFhit at the Protein Data Bank. Download reprint
J.R. Boyne, H.M. Yosuf, P. Bieganowski, C. Brenner & C. Price, “Yeast Myosin Light Chain, Mlc1p, Interacts with Both IQGAP and Class II Myosin to Effect Cytokinesis,” J Cell Science, v. 113, pp. 4533-4543 (2000). Download reprint
H.C. Pace & C. Brenner, “The Nitrilase Superfamily: Classification, Structure and Function,” Genome Biology, v. 2, pp. reviews0001.1-0001.9 (2001). Download reprint. See supplemental data file at Genome Biology.
L. Daheron, T. Zenz, L.D. Siracusa, C. Brenner & B. Calabretta, ” Molecular Cloning of Ian4: a BCR/ABL-Induced Gene that Encodes an Outer Membrane Mitochondrial Protein with GTP-Binding Activity, ” Nucleic Acids Research, v. 29, pp. 1308-1316 (2001). Download reprint
A.G. McLennan, L.D. Barnes, G.M. Blackburn, C. Brenner, A. Guranowski, A.D. Miller, J.M. Rovira, P. Rotllan, B. Soria, J.A. Tanner & A. Sillero, “Recent Developments in the Study of the Intracellular Function of Diadenosine Polyphosphates,” Drug Development Research, v. 52, pp. 249-259 (2001). Download reprint
J.M. Varnum, J. Baraniak, R. Kaczmarek, W.J. Stec & C. Brenner, “Di-, Tri- and Tetra-5-O-Phosphorothioadenosyl Substituted Polyols as Inhibitors of Fhit: Importance of the Alpha-Beta Bridging Oxygen and Beta Phosphorus Replacement, ” BMC Chemical Biology, v. 1, 3 (2001). Download reprint
D.H. Klaubert, K.R. Gee & C.M. Brenner, “Phosphate-Bound Polyazaindacene Derivatives of Nucleotides,” US Patent 6,323,186, issued November 27, 2001. Download reprint
S.K. Milano, H.C. Pace, Y.-M. Kim, C. Brenner & J. Benovic, “Scaffolding Functions of Arrestin-2 Revealed by Crystal Structure and Mutagenesis,” Biochemistry, v. 41, pp. 3321-3328 (2002). View Arrestin-2 at the Protein Data Bank. Download reprint
P. Bieganowski, P.N. Garrison, S.C. Hodawadekar, G. Faye, L.D. Barnes & C. Brenner, “Adenosine Monophosphoramidase Activity of Hint and Hnt1 Supports Function of Kin28, Ccl1 and Tfb3, ” J Biol Chem, v. 277, pp. 10852-10860 (2002). Download reprint
M. Rubio-Texeira, J.M. Varnum, P. Bieganowski & C. Brenner, “Control of Dinucleoside Polyphosphates by the FHIT-Homologous HNT2 Gene, Adenine Biosynthesis, and Heat Shock in Saccharomyces cerevisiae,” BMC Molecular Biology, v. 3, 7 (2002). Download reprint
C. Brenner, “Hint, Fhit and GalT: Function, Structure, Evolution and Mechanism of Three Branches of the Histidine Triad Superfamily of Nucleotide Hydrolases and Transferases,” Biochemistry, v. 41, pp. 9003-9014 (2002). Download reprint
A. Owczarek, R. Kaczmarek, B. Mikolajczyk, E. Wasilewska, D. Korczynski, J. Baraniak, M. Koziolkiewicz, W.J. Stec WJ & C. Brenner, “Stereochemical analysis of diastereomeric 1,3-bis(adenosine-5′-O-phosphorothioyl)glycerols,”Nucleosides, Nucleotides and Nucleic Acids, v. 22, pp. 797-9 (2003).
F. Trapasso, A. Krakowiak, R. Cesari, J. Arkles, S. Yendamuri, H. Ishii, A. Vecchione, T. Kuroki, P. Bieganowski, H.C. Pace, K. Huebner, C.M. Croce & C. Brenner, “Designed FHIT Alleles Establish that Fhit-Induced Apoptosis in Cancer Cells is Limited by Substrate-Binding,” Proc Natl Acad Sci, v. 100, pp. 1592-1597 (2003). Download reprint
H.C. Pace & C. Brenner, “Feminizing Chicks: A Model for Avian Sex Determination Based on Titration of Hint Enzyme Activity and the Predicted Structure of an Asw-Hint Heterodimer,” Genome Biology, v. 4, R18 (2003). Download reprint
P. Bieganowski, H.C. Pace & C. Brenner, “Eukaryotic NAD+ Synthetase Qns1 Contains an Essential, Obligate Intramolecular Thiol Glutamine Amidotransferase Domain Related to Nitrilase,” J Biol Chem, v. 278, pp. 33049-33055 (2003). Download reprint
P. Bieganowski & C. Brenner, “The Reported Human NADsyn2 is Ammonia-Dependent NAD+ synthetase from a Pseudomonad,” J Biol Chem, v. 278, pp. 33056-33059 (2003). Download reprint
C. Brenner, “Subtleties Among Subtilases: Structural Biology of Kex2 and Furin-Related Prohormone Convertases,”EMBO Reports, v. 4, pp. 937-938 (2003). Download reprint
D.A. Kwasnicka, A. Krakowiak, C. Thacker, C. Brenner & S.R. Vincent, ” Coordinate Expression of NADPH-Dependent Flavin Reductase, FRE-1, and Hint-Related 7meGMP-Directed Hydrolase, DCS-1,” J Biol Chem, v. 278, pp. 39051-39058 (2003). Download reprint
A. Krakowiak, H.C. Pace, G. Michael Blackburn, M. Adams, A. Mekhalfia, R. Kaczmarek, J. Baraniak, W.J. Stec & C. Brenner, “Biochemical, Crystallographic and Mutagenic Characterization of Hint, the AMP-Lysine Hydrolase, with Novel Substrates and Inhibitors,” J Biol Chem, v. 279, pp. 18711-18716 (2004). View Hint-N-ethylsulfamoyl adenosine at the Protein Data Bank. Download reprint
T.M. Maiolatesi & C. Brenner, “Chemical and Genetic Methods to Validate Targets in Non-Mammalian Organisms,” chapter 10 of Oncogenomics: Molecular Approaches to Cancer, C. Brenner and D. Duggan, Eds., John Wiley & Sons, (2004). View the Oncogenomicsposter, the site at Wiley, or Amazon. Download book review in the New England Journal of Medicine.
P. Bieganowski & C. Brenner, “Discoveries of Nicotinamide Riboside as a Nutrient and Conserved NRK Genes Establish a Preiss-Handler Independent Route to NAD+ in Fungi and Humans,” Cell, v. 117, pp. 495-502 (2004). Download reprint
P. Bieganowski, K. Shilinski, P.N. Tsichlis & C. Brenner, “Cdc123 and Checkpoint Forkhead Associated With RING Proteins Control the Cell Cycle By Controlling eIF2gamma Abundance, ” J Biol Chem, v. 279, pp. 44656-44666 (2004). Download reprint
P.M. Clements, C. Breslin, E.D. Deeks, P.J. Byrd, L. Ju, P. Bieganowski, C. Brenner, M.-C. Moreira, A.M.R. Taylor & K.W. Caldecott, “The ataxia-oculomotor apraxia 1 gene product has a role distinct from ATM and interacts with the DNA strand break repair proteins XRCC1 and XRCC4,” DNA Repair, v. 3, pp. 1493-1502 (2004). Download reprint
K.P. Parks, H. Seidle, N. Wright, J.B. Sperry, P. Bieganowski, K. Howitz, D.L. Wright & C. Brenner, “Altered Specifity of Hint-W123Q Supports a Role for Hint Inhibition by Asw in Avian Sex Determination,” Physiological Genomics, v. 20, pp. 12-14 (2004). Download reprint and supplemental data
T.-F. Chou, P. Bieganowski, K. Shilinski, J. Cheng, C. Brenner & C.R. Wagner, “31P NMR and Genetic Analysis Establish hinT as the only E. coli Purine Nucleoside Phosphoramidase and as Essential for Growth Under High Salt Conditions,” J Biol Chem, v. 280, pp. 15356-15361 (2005). Download reprint and supplemental data
H.F. Seidle, P. Bieganowski & C. Brenner, “Disease-Associated Mutations Inactivate AMP-Lysine Hydrolase Activity of Aprataxin,” J Biol Chem, v. 280, pp. 20927-20931 (2005). View or download JBC Paper of the Week Summary. Download reprint and supplemental data
C. Brenner, “Evolution of NAD Biosynthetic Enzymes,” Structure, v. 13, pp. 1239-1240 (2005). Download reprint
S.K. Milano, Y.-M. Kim, F.P. Stefano, J.L. Benovic & C. Brenner, “Nonvisual Arrestin Oligomerization and Cellular Localization are Regulated by Inositol Hexakisphosphate Binding,” J Biol Chem, v. 281, pp. 9812-9823 (2006). View Arrestin-2-IP6 entry at the Protein Data Bank. Download reprint and supplemental data
J. Martin, F. Magnino, K. Schmidt, A.-C. Piguet, J.-S. Lee, D. Semela, M.V. St-Pierre, A. Ziemiecki, D. Cassio, D. Mochly-Rosen, C. Brenner, S.S. Thorgeirsson & J.-F. Dufour, “Hint2, a Mitochondrial Apoptotic Sensitizer Downregulated in Hepatocellular Carcinoma,” Gastroenterology, v. 130, pp. 2179-2188 (2006). Download reprint
P. Bieganowski, H.F. Seidle, M. Wojcik & C. Brenner, “Synthetic Lethal and Biochemical Analyses of NAD and NADH Kinases in Saccharomyces cerevisiae Establish Separation of Cellular Functions,” J Biol Chem, v. 281, pp. 22439-22445 (2006). Download reprint
A.B. Parsons, A. Lopez, I.E. Givoni, D.E. Williams, C.A. Gray, J. Porter, G. Chua, R. Sopko, R.L. Brost, C.-H. Ho, J. Wang, T. Ketela, C. Brenner, J.A. Brill, G.E. Fernandez, T.C. Lorenz, G.S. Payne, S. Ishihara, Y. Ohya, B. Andrews, T.R. Hughes, B.J. Frey, T.R. Graham, R.J. Andersen & C. Boone, “Exploring the Mode-of-Action of Bioactive Compounds by Chemical-Genetic Profiling in Yeast,” Cell, v. 126, pp. 611-6255 (2006). Download reprint. Examine supplementary data.
M. Wojcik, H.F. Seidle, P. Bieganowski & C. Brenner, “Glutamine-Dependent NAD+ synthetase: How a Two-Domain, Three-Substrate Enzyme Avoids Waste,” J Biol Chem, v. 281, pp. 33395-33402 (2006). Download reprint
C.L. Linster, T.A. Gomez, K.C. Christensen, L.N. Adler, B.D. Young, C. Brenner & S.G. Clarke, “Arabidopis VTC2 Encodes GDP-L-Galactose Phosphorylase, the Last Unknown Enzyme in the Smirnoff-Wheeler Pathway to Ascorbic Acid in Plants,” J Biol Chem, v. 282, pp. 18879-18885 (2007). Download reprint. View JBC Paper of the Week Summary.
R.S. Fuller, R.A. Bambara, T. Baker, B. Funnell, E. Wahle, M. O’Donnell, D. Kaiser, K. Skarstad, B. Konforti, S. Maki, T. Katayama, K. Sekimizu, J.H. Weiner, R.W. Davis, L. Rowen, M.F. Goodman, J. Spudich, S. Pfeffer, C.C. Richardson, P. Polaczek, R. Calendar, R. Kolodner, J. Griffith, B. Stillman, P. Modrich, C. Brenner & C. Yanofsky, “A Tribute to Arthur Kornberg, 1918-2007,” Nat Struct Mol Biol, v. 15, pp. 2-17 (2008). Download reprint
G.L. Loring, K.C. Christensen, S.A. Gerber & C. Brenner, “Yeast Chfr Homologs Retard Cell Cycle at G1 and G2/M via Ubc4 and Ubc13/Mms2-Dependent Ubiquitination,” Cell Cycle, v. 7, pp. 95-105 (2008). Download reprint and supplementary data
P.A. Belenky, T.G. Mogu & C. Brenner, “S. cerevisiae YOR071C Encodes the High Affinity Nicotinamide Riboside Transporter, Nrt1,” J Biol Chem, v. 283, pp. 8075-8079 (2008). Download reprint and supplementary data
K.L. Bogan & C. Brenner, “Nicotinic Acid, Nicotinamide, and Nicotinamide Riboside: A Molecular Evaluation of NAD+ Precursor Vitamins in Human Nutrition,” Ann Review Nutrition, v. 28, pp. 115-130 (2008). Download reprint
C.L. Linster, L.T. Adler, K. Webb, K.C. Christensen, C. Brenner & S.G. Clarke, “A Second GDP-L-Galactose Phosphorylase in Arabidopsis en Route to Vitamin C: Covalent Intermediate and Substrate Requirements for the Conserved Reaction,” J Biol Chem, v. 283, pp. 18483-18492 (2008). Download reprint
L. Brooks,III, E.G. Heimsath, Jr., G.L. Loring & C. Brenner, “FHA-RING Ubiquitin Ligases in Cell Division Cycle Control,” Cell Mol Life Sci, v. 65, cover and pp. 3458-3466 (2008). Download reprint
P. Belenky, K.C. Christensen, F. Gazzaniga, A.A. Pletnev & C. Brenner, “Nicotinamide Riboside and Nicotinic Acid Riboside Salvage in Fungi and Mammals: Quantitative Basis for Urh1 and Purine Nucleoside Phosphorylase Function in NAD+ Metabolism,” J Biol Chem, v. 284, pp. 158-164 (2009). Download reprint
P. Bieganowski & C. Brenner, “Nicotinamide Riboside Kinase Compositions and Methods for Using the Same,”Australian Patent 2005211773, issued June 1, 2009.
F. Gazzaniga, R. Stebbins, S. Z. Chang, M.A. McPeek & C.Brenner, “Microbial NAD Metabolism: Lessons from Comparative Genomics, “Microbiol Mol Biol Rev, v. 73, pp. 529-541 (2009). Download reprint
K.L. Bogan, C. Evans, P. Belenky, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, ” Identification of Isn1 and Sdt1 as Glucose and Vitamin-regulated NMN and NaMN 5′-nucleotidases Responsible for Production of Nicotinamide Riboside and Nicotinic Acid Riboside,” J Biol Chem, v. 284, pp. 34861-34869 (2009). Download reprint and supplementary data
C. Evans, K.L. Bogan, P. Song, C.F. Burant, R.T. Kennedy & C. Brenner, “NAD+ Metabolite Levels as a Function of Vitamins and Calorie Restriction: Evidence for Different Mechanisms of Longevity,” BMC Chem Biol, v. 10, 2 (2010). Download reprint and supplementary data
K.L. Bogan & C. Brenner, “5′-Nucleotidases and their New Roles in NAD+ and Phosphate Metabolism,” New Journal of Chemistry, v. 34, pp. 845-853 (2010). Download reprint
F. Syeda, R.L. Fagan, M. Wean, G.V. Awakumov, J.R. Walker, S. Xue, S. Dhe-Paganon & C. Brenner, “The RFTS Domain is a DNA-Competitive Ingibitor of Dnmt1,” JBC, v. 286, pp. 15344-15351 ( 2011). Download reprint
C. Brenner. “On the Nonspecific Degradation of NAD+ to Nicotinamide Riboside,” JBC, v. 286, p. le5 (2011). Download reprint
P. Belenky, R. Stebbins, K.L. Bogan, C.R. Evans & C. Brenner, “Nrt1 and Tna1-Independent Export of NAD+ Precursor Vitamins Promotes NAD+ Homeostasis and Allows Engineering of Vitamin Production,” PLoS ONE, v. 6, p. e19710 (2011). Download reprint
C. Brenner, “Rethinking Premedical and Health Professional Curricula in Light of MCAT 2015,” Journal of Chemical Education, v. 90, pp. 807-812 (2013). DOI:10.1021/ed4002738. Download reprint
R.L. Fagan, D.E. Cryderman, L. Kopelovich, L.L. Wallrath & C. Brenner, “Laccaic Acid A is a Direct, DNA-Competitive Inhibitor of DNA Methyltransferase 1,” J Biol Chem, v.288, pp. 23858-23867 (2013). DOI: 10.1074/jbc.M113.480517. Download reprint.
C. Brenner, “Demystifying the Chalk Talk,” ASBMB Today, v. 12, number 8, pp. 33-35 (2013). Download reprint
S. Ghanta, R.E. Grossmann & C. Brenner, “Mitochondrial protein acetylation as a cell-intrinsic, evolutionary driver of fat storage: chemical and metabolic logic of acetyl-lysine modifications” Critical Rev Biochem & Mol Biol, v. 48, pp. 561-574 (2013). Download reprint.
P.J. Kennelly, J.S. Bond, B.S. Masters, E.A. Dennis, C. Brenner & D.M. Raben, “Desperately Seeking Flexner: Time to Reemphasize Basic Science in Medical Education” Academic Medicine, v. 88, pp. 1405-1406 (2013). DOI: 10.1097/ACM.0b013e3182a225be. Download reprint
R.L. Fagan, M. Wu, F. Chédin & C. Brenner, “An Ultrasensitive High Throughput Screen for DNA Methyltransferase 1-targeted Molecular Probes” PLoS One, v. 11,e78752 (2013). Download reprint.
S-C. Mei & C. Brenner, “NAD as a Genotype-Specific Drug Target” Chemistry & Biology, v. 20, pp. 1307-1308 (2013). Download reprint
J. Huang, A. Stewart, B. Maity, J. Hagen, R.L. Fagan, J. Yang, D.E. Quelle, C. Brenner & R.A. Fisher, “RGS6 Suppresses Ras-inducded Cellular Transformation by Facilitating Tip60-mediated Dnmt1 Degradation and Promoting Apoptosis,”Oncogene, v. 33, pp. 3604-11 (2014). DOI:10.1038/onc.2013.324. Download reprint
C. Brenner, “Understanding Faculty Salaries,” ASBMB Today, v. 13, number 1, pp. 28-29 (2014). Download reprint
C. Brenner, “Metabolism: Targeting a fat-accumulation gene” Nature, v. 508, pp. 194-195 (2014). DOI: 10.1038/508194a. Download reprint.
C. Brenner, “Histidine Triad Superfamily” Encyclopedia of Life Sciences, John Wiley & Sons Ltd: Chichester (2014). DOI: 10.1002/9780470015902.a0020545.pub2.
J.A. Boylston & C. Brenner, “A Knockdown with Smoke Model Reveals Fhit as a Repressor of Heme Oxygenase 1,” Cell Cycle, v. 13, pp. 2913-30 (2014). DOI:10.4161/15384101.2014.946858. Download reprint
B.-K. Wu, S.-C. Mei & C. Brenner, “RFTS-deleted DNMT1 enhances tumorigenicity with focal hypermethylation and global hypomethylation,” Cell Cycle, v. 13, pp. 3222-3231 (2014). DOI:10.4161/15384101.2014.950886. Download reprint
S.-C. Mei & C. Brenner, “Quantification of Protein Copy Number in Yeast: the NAD+ Metabolome,” PLoS One v. 9, e106496 (2014). DOI: 10.1371/journal.pone.0106496. Download reprint
B.-K. Wu & C. Brenner, “Suppression of TET1-Dependent DNA Demethylation is Essential for KRAS-Mediated Transformation,” Cell Reports, v. 9, pp. 1827-1840 (2014). DOI:10.1016/j.celrep.2014.10.063. Download reprint
C. Brenner, “Boosting NAD to Spare Hearing,” Cell Metabolism, v. 21, pp.926-927 (2014). DOI: 10.1016/j.cmet.2014.11.015. Download reprint.
S.-C. Mei & C. Brenner, “Calorie Restriction-Mediated Replicative Lifespan Extension in Yeast Is Non-Cell Autonomous,” PLoS Biology, v. 13, e1002048 (2015). Download reprint
S.A.J. Trammell & C. Brenner, “NNMT: A Bad Actor in Fat Makes Good in Liver,” Cell Metabolism, v. 22, pp. 200-201 (2015). DOI:10.1016/j.cmet.2015.07.017. Download reprint
S.A.J. Trammell, L. Yu, P. Redpath, M.E. Migaud & C. Brenner, “Nicotinamide Riboside Is a Major NAD+ Precursor Vitamin in Cow Milk,” The Journal of Nutrition, v. 146, pp. 957-963 (2016). DOI: 10.3945/jn.116.230078. Download reprint
S.A.J. Trammell, B.J.Weidemann, A.Chadda, M.S. Yorek, A. Holmes, L.J.Coppey, A. Obrosov, R.H. Kardon, M.A. Yorek & C. Brenner, “Nicotinamide Riboside Opposes Type 2 Diabetes and Neuropathy in Mice,” Scientific Reports, v. 6, 26933 (2016). DOI: 10.1038/srep26933. Download reprint
S.A.J Trammell, M.S. Schmidt, B.J. Weidemann, P. Redpath, F. Jaksch, R.W. Dellinger, Z. Li, E.D. Abel, M.E. Migaud & C. Brenner, “Nicotinamide riboside is uniquely and orally bioavailable in mice and humans.” Nat Commun. v. 7, pp. 12948 (2016). DOI: 10.1038/ncomms12948. Download reprint
J. Ratajczak, M. Joffraud, S.A.J. Trammell, R. Ras, N. Canela, M. Boutant, S.S. Kulkarni, M. Rodrigues, P. Redpath, M.E. Migaud, J. Auwerx, O. Yanes, C. Brenner & C. Canto, “NRK1 controls nicotinamide mononucleotide and nicotinamide riboside metabolism in mammalian cells.” Nat Commun. v. 7, pp. 13103 (2016). DOI: 10.1038/ncomms13103. Download reprint.
J.L. Wilsbacher, M. Cheng, D. Cheng, S.A.J. Trammell, Y. Shi, J. Guo, S.L. Koeniger, P.J. Kovar, Y. He, S. Jagadeeswaran, H.R. Heyman, B.K. Sorensen, R.F. Clark, T.M. Hansen, K.L. Longenecker, D. Raich, A.V. Korepanova, D.L. Towne, V.C. Abraham, H. Tang, S.M. McLoughlin, M.L. Curtin, M.R. Michaelides, D. Maag, F.G. Buchanan, W. Gao, S.H. Rosenberg, C. Brenner & C. Tse, “Discovery and Characterization of Novel, Orally Bioavailable Non-substrate and Substrate NAMPT Inhibitors,” Molecular Cancer Therapeutics, v. 16, pp. 1236-1245 (2017). DOI:10.1158/1535-7163.MCT-16-0819. Download reprint.
M.V. Hamity, S.R. White, R.Y. Walder, M.S. Schmidt, C. Brenner & D.L. Hammond, “Nicotinamide Riboside, a Form of Vitamin B3 and NAD+ Precursor, Relieves the Nociceptive and Aversive Dimensions of Paclitaxel-induced Peripheral Neuropathy in Female Rats,” Pain, v. 158, pp. 962–972 (2017). DOI: 10.1097/j.pain.0000000000000862. Download reprint.
R. Fletcher, J. Ratajczak, C.L. Doig, L.A. Oakey, R.Callingham, G. da Silva Xavier, A. Garten, Y.S. Elhassan, P. Redpath, M.E. Migaud, A. Philp, C. Brenner, C. Canto & G.G. Lavery, “Nicotinamide Riboside Kinases Display Redundancy in Mediating Nicotinamide Mononucleotide and Nicotinamide Riboside Metabolism in Skeletal Muscle Cells,” Molecular Metabolism, v. 6 (2017). DOI: 10.1016/j.molmet.2017.05.011. Download reprint.
P. Vaur, B. Brugg, M. Mericskay, Z. Li, M.S. Schmidt, D. Vivien, C. Orset, E. Jacotot, C. Brenner & E. Duplus, “Nicotinamide riboside, a form of vitamin B3, protects against excitotoxicity-induced axonal degeneration,”FASEB Journal (2017). DOI: 10.1096/fj.201700221RR. Download reprint.
S.Thakur & C. Brenner, “KRAS-driven miR-29b Expression is Required for Tumor Suppressor Gene Silencing,” Oncotarget, v.8(43), pp. 74755-74766 (2017). DOI: 10.18632/oncotarget.20364. Download reprint.
S. Sato, G. Solanas, F.O. Peixoto, L. Bee, A. Symeonidi, M.S. Schmidt, C. Brenner, S. Masri, S.A. Benitah & P. Sassone-Corsi, “Circadian Reprogramming Identifies Metabolic Pathways of Aging,” Cell, v. 170(4), pp. 664-677 (2017). DOI: 10.1016/j.cell.2017.07.042. Download reprint.
N. Diguet, S.A.J. Trammell, C. Tannous, R. Deloux, J. Piquereau, N. Mougenot, A. Gouge, M. Gressette, B. Manoury, J. Blanc, M. Breton, J.F. Decaux, G. Lavery, I. Baczkó, J. Zoll, A. Garnier, Z. Li, C. Brenner & M. Mericskay, “Nicotinamide Riboside Preserves Cardiac Function in a Mouse Model of Dilated Cardiomyopathy,” Circulation, v. 137(21), pp. 2256-2273 (2018). DOI: 10.1161/CIRCULATIONAHA.116.026099. Download reprint. Read accompany commentary
Fangmann, E.M. Theismann, K. Türk, D.M. Schulte, I. Relling, K. Hartmann, J.K. Keppler, J.R. Knipp, A. Rehman, F.A. Heinsen, A. Franke, L. Lenk, S. Freitag-Wolf, E. Appel, S. Gorb, C. Brenner, D. Seegert, G.H. Waetzig, P. Rosenstiel, S. Schreiber, K. Schwarz & M. Laudes, “Targeted Microbiome Intervention by Microencapsulated Delayed-Release Niacin Beneficially Affects Insulin Sensitivity in Humans,” Diabetes Care, v. 41(3), pp. 398-405 (2018). DOI: 10.2337/dc17-1967. Download reprint.
D.S. Matasic, C. Brenner & B. London, “Emerging Potential Benefits of Modulating NAD+ Metabolism in Cardiovascular Disease,” Am J Physiol Heart Circ Physiol, v. 314(4), pp. H839-H852 (2018). DOI: 10.1152/ajpheart.00409.2017. Download reprint.
O.L. Dollerup, B.Christensen, M. Svart, M.S. Schmidt, K. Sulek, S. Ringgaard, H. Stødkilde-Jørgensen, N. Møller, C. Brenner, J.T. Treebak &N. Jessen, “A randomized placebo-controlled clinical trial of nicotinamide riboside in obese men: safety, insulin-sensitivity, and lipid-mobilizing effects,” Am J Clin Nutr., v.108(2), pp. 343-353 (2018). DOI: 10.1093/ajcn/nqy132. Download reprint.
S.J. Mitchell, M. Bernier, M.A. Aon, S. Cortassa, E.Y. Kim, E.F. Fang, H.H. Palacios, Ali A1, I. Navas-Enamorado, A. Di Francesco, T.A. Kaiser, T.B. Waltz, N. Zhang, J.L. Ellis, P.J. Elliott, D.W. Frederick, V.A. Bohr, M. S. Schmidt, C. Brenner, D.A. Sinclair, A. A. Sauve, J.A. Baur & R. de Cabo, “Nicotinamide Improves Aspects of Healthspan, but Not Lifespan, in Mice,” Cell Metab. 27(3):667-676.e4 (2018). DOI: 10.1016/j.cmet.2018.02.001. Download reprint.
H.W. Liu, C.B. Smith, M.S. Schmidt, X.A. Cambronne, M.S. Cohen, M.E. Migaud, C. Brenner & R.H. Goodman, “Pharmacological bypass of NAD+ salvage pathway protects neurons from chemotherapy-induced degeneration,” Proc Natl Acad Sci U S A. v.115 (42), pp.10654-10659 (2018). DOI: 10.1073/pnas.1809392115. Download reprint
C. Brenner & A.C. Boileau, “Pterostilbene Raises Low Density Lipoprotein Cholesterol in People,” Clinical Nutrition. v.38(1), pp.480-481 (2019), DOI:10.1016/j.clnu.2018.10.007. Download reprint.
P. H. Ear, A. Chadda, S. B. Gumusoglu, M. S. Schmidt, S. Vogeler, J. Malicoat, J. Kadel, M. M. Moore, M. E. Migaud, H. E. Stevens & C. Brenner, “Maternal Nicotinamide Riboside Enhances Postpartum Weight Loss, Juvenile Offspring Development, and Neurogenesis of Adult Offspring,” Cell Reports. v. 26 (4), pp. 969-983 (2019). DOI: 10.1016/j.celrep.2019.01.007. Download reprint.
W. Shi, M.A. Hegeman, A. Doncheva, I. van der Stelt, M. Bekkenkamp-Grovenstein, E. M. van Schothorst, C.Brenner, V. C. J. de Boer & J. Keijer, “Transcriptional Response of White Adipose Tissue to Withdrawal of Vitamin B3,” Mol Nutr Food Res., v. 2019. DOI: 10.1002/mnfr.201801100. Dowload reprint
D. Conze, C. Brenner, & C.L. Kruger, “Safety and Metabolism of Long-Term Administration of Niagen (Nicotinamide Riboside Chloride) in a Randomized, Double-Blind, Placebo-controlled Clinical Trial of Healthy Overweight Adults,” Scientific Reports, v. 9, 9772, 2019. DOI: 10.1038/s41598-019-46120-z. Download reprint
M.S. Schmidt, & C. Brenner, “Absence of evidence that Slc12a8 Encodes a Nicotinamide Mononucleotide Transporter,” Nature Metabolism, v. 1, pp. 660-661 (2019). DOI: 10.1038/s42255-019-0085-0. Download reprint
Y.S. Elhassan, K. Kluckova, R.S. Fletcher, M.S. Schmidt, A. Garten, C.L. Doig, D.M. Cartwright, L. Oakey, C.V. Burley, N Jenkinson, M. Wilson, S.J.E. Lucas, I. Akerman, A. Seabright, Y.C. Lai, D.A. Tennant, P. Nightingale, G.A. Wallis, K.N. Manolopoulos, C. Brenner, A. Philip, G.G. Lavery, “Nicotinamide Riboside Augments the Human Skeletal Muscle NAD Metabolome and Induces Transcriptomic ad Anti-inflammatory Signatures in Aged Subjects: a Placebo-controlled, Randomized Trial,” Cell Reports, v. 28, 7 2019. DOI: 10.1016/j.celrep.2019.07.043. Download reprint
C. Brenner, “Why Is Mom Stressed: Homeorhesis as the Potential Problem and Nicotinamide Riboside as the Potential Solution,” Journal of Experimental Neuroscience v. 13, pp. 1-3 (2019). DOI: 10.1177/1179069519869679. Download reprint
N.R. Fons, R.K. Sundaram, G.A. Breuer, S. Peng, R.L. McLean, A.N. Kalathil, M.S. Schmidt, D.M. Carvalho, A. Mackay, C. Jones, A.M. Carcaboso, J. Nazarian, M.E. Berens, C. Brenner, & R.S. Bindra., “PPM1D mutations silence NAPRT gene expression and confer NAMPT inhibitor sensitivity in glioma,” Nature Communications, v. 10, 3790 (2019). DOI: 10.1038/s41467-019-11732-6. Download reprint
D.S. Matasic, J-T. Yoon, H. Mehdi, J.M. McLendon, M.S. Schmidt, A.M. Greiner, P. Quinones, G.M. Morgan, R. Bourdreau, K. Irani, C. Brenner & B. London., “Modulation of the Cardiac Sodium Channel Nav1.5 Peak and Late Currents by NAD+ Precursors,” Journal of Molecular and Cellular Cardiology., J Mol Cell Cardiol v. 141, pp. 70-81, (2020) DOI: 10.1016/j.yjmcc.2020.01.013 Download reprint
E. Pirinen, M. Auranen, N. Khan, V. Brilhante, N. Urho, A. Pessia, A. Hakkarainen, J. Kuula, U. Heinonen, M.S. Schmidt, K. Haimilahti, P. Piirila, N. Lundbom, M.R. Taskinen, C. Brenner, V. Velagapudi, K. Pietilainen & A. Suomalainen, “Niacin Cures Systematic NAD+ Deficiency and Improves Muscle Performance in Adult-Onset Mitochondrial Myopathy,” Cell Metabolism, v. 31, pp. 1078-1090 May 2020. DOI: 10.1016/j.cmet.2020.04.008 Download reprint
D.C. Levine, H. Hong, K.M. Ramsey, A.H. Affinati, M.S. Schmidt, J. Cedernaes, C. Omura, C. Lee, C. Brenner, C.B. Peek & J. Bass. “NAD+ Controls Circadian Reprogramming Through PER2 Nuclear Translocation to Counter Aging,” Molecular Cell v. 78 pp. 835-849, May, 2020. DOI: 10.1016/j.molcel.2020.04.010 Download reprint
N.T. Fluharty & C. Brenner, “Fat Mobilization Without Weight Loss is a Potentially Rapid Response to Nicotinamide Riboside in Obese People: It’s Time to Test with Exercise,” American Journal of Clinical Nutrition, May, 2020. DOI: 10.1093/ajcn/nqaa109 Download reprint
C.D. Heer & C. Brenner, “Letting off Electrons to Cope with Metabolic Stress,” Nature Metabolism, v. 2, pp. 485-486, May 2020 DOI: 10.1038/s42255-020-0207-8 Download reprint
R. Parker, M.S. Schmidt, O. Cain, B. Gunson & C. Brenner, “The NAD+ Metabolome is Functionally Depressed in Patients Undergoing Liver Transplantation for Alcohol-related Liver Disease,” Hepatology Communications, May 2020 DOI: 10.1002/hep4.1530 Download reprint
M. Gerasimenko, S. Cherepanov, K. Furuhara, O. Lopatina, A. Salmina, A. Shabalova, C. Tsuji, S. Yokoyama, K. Ishihara, C. Brenner & H. Higashida, “Nicotinamide Riboside Supplementation Corrects the Deficits in Oxytocin, Sociability and Anxiety of CD157 Mutants in a Mouse Model of Autism Spectrum Disorder,” Scientific Reports, v. 10, 10035, 2020 DIO: 10.1038/s4198-029-57236-7 Download reprint
B.C. Gilmour, R. Gudmundsrud, J. Frank, A. Hov, S. Lautrup, Y. Aman, H. Røsjø, C. Brenner, M. Ziegler, O.B. Tysnes, C. Tzoulis, T. Omland, A. Søraas, T. Holmøy, L.H. Bergersen, J. Storm-Mathisen, H. Nilsen & E.F. Fang, “Targeting NAD+ in Translational Research to Relieve Diseases and Conditions of Metabolic Stress and Ageing,” Mechanisms of Ageing and Development v. 186, 2020, DOI: 10.1016/j.mad.2020. 111208 Download reprint
T.S. Nam, D.R. Park, S.-Y. Rah, T.G. Woo, H.T. Chung, C. Brenner & U.-H. Kim. “Interleukin-8 drives CD38 to form NAADP from NADP+ and NAAD in the endolysosomes to mobilize Ca2+ and effect cell migration” FASEB Journal DOI: 10.1101/2020.03.24.004739 Download reprint
X. Zhang, N. F. Henneman, P. E. Girardot, J. T. Sellers, M. A. Chrenek, Y. Li, J. Wang, C. Brenner, J. M. Nickerson, J. H. Boatright, “Systemic Treatment With Nicotinamide Riboside Is Protective in a Mouse Model of Light-Induced Retinal Degeneration” Invest. Ophthalmol. Vis. Sci. 2020;61(10):47. DOI: https://doi.org/10.1167/iovs.61.10.47 Download reprint
C.D. Heer, D. J. Sanderson, L.S. Voth, Y M.O Alhammad, M.S. Schmit, S.A.J. Trammell, S. Perlan, M.S. Cohen, A.R. Fehr, C. Brenner “Coronavirus infection and PARP expression dysregulate the NAD Metabolome: an actionable component of innate immunity” J. Biol. Chem. jbc.RA120.015138. DOI:10.1074/jbc.RA120.015138 Download reprint
A.J. Covarrubias, A. Kale, R. Perrone, J.A. Lopez-Dominguez, A. O. Pisco, H. G. Kasler, M. S. Schmidt, I. Heckenbach, R. Kwok, C. D. Wiley, H-S Wong, E. Gibbs, S. S. Iyer, N. Basisty, Q. Wu, I-J Kim, E. Silva, K. Vitangcol, K-O Shin, Y-M Lee, R. Riley, I. Ben-Sahra, M. Ott, B. Schilling, M. Scheibye-Knudsen, K. Ishihara, S. R. Quake, J. Newman, C. Brenner, J. Campisi, E. Verdin “Senescent cells promote tissue NAD+ decline during ageing via the activation of CD38+ macrophages” Nat Metab2, 1265–1283 (2020). DOI: 10.1038/s42255-020-00305-3 Download reprint
R. Ghugari, S. Tsao, M. Schmidt, E. Bonneil, C. Brenner, A. Verreault “Mechanisms to reduce the cytotoxicity of pharmacological nicotinamide concentrations in the pathogenic fungus Candida albicans” FebsPress DOI 10.1111/febs.15622 Download preprint